American Journal of Epidemiology Vol. 153, No. 1 : 11-19
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Risk Factors for Uterine Leiomyoma: A Practice-based Case-Control Study. II. Atherogenic Risk Factors and Potential Sources of Uterine Irritation
1 Department of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
2 Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD.
3 Department of Gynecology and Obstetrics, School of Medicine, Johns Hopkins University, Baltimore, MD.
In this case-control study, the authors analyzed associations of uterine leiomyoma with atherogenic risk factors and potential sources of uterine irritation. The study included 318 case women with uterine leiomyoma that was first confirmed between 1990 and 1993 in the Baltimore, Maryland, area and 394 controls selected from women visiting the same gynecologists' offices for routine reasons. Telephone interviews were conducted with 77.8% of eligible cases and 78.0% of eligible controls. Compared with participants with no hypertension history, increased risks were observed among participants with any history of hypertension (odds ratio (OR) = 1.7; 95% confidence interval (CI): 1.0, 2.8), hypertension requiring medication (OR = 2.1; 95% CI: 1.1, 4.1), hypertension diagnosed at ages less than 35 years (for hypertension requiring medication, OR = 2.7; 95% CI: 1.0, 7.6), and hypertension of 5 or more years' duration (for hypertension requiring medication, OR = 3.1; 95% CI: 1.2, 8.2). Estimates of associations with diabetes history were very imprecise but followed similar patterns. Adjusted associations were observed with pelvic inflammatory disease (three or more episodes vs. none: OR = 3.7; 95% CI: 0.9, 15.9), chlamydial infection (history vs. no history: OR = 3.2; 95% CI: 0.8, 13.7), and use of an intrauterine device when it caused infectious complications (use vs. no use: OR = 5.3; 95% CI: 1.8, 16.3). Risk of uterine leiomyoma was also associated in a graded fashion with frequency of perineal talc use (daily use vs. no use: OR = 2.2; 95% CI: 1.4, 3.1). The authors conclude that nonhormonal factors may influence risk of uterine leiomyoma.
adnexitis; case-control studies; hypertension; intrauterine devices; irritants; leiomyoma; risk factors; uterine diseases
Abbreviations: CI, confidence interval; IUD, intrauterine device; PID, pelvic inflammatory disease; UL, uterine leiomyoma
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Isobe, T. Takeda, M. Sakata, A. Miyake, T. Yamamoto, R. Minekawa, F. Nishimoto, Y. Oskamoto, C. L. Walker, and T. Kimura Dual repressive effect of angiotensin II-type 1 receptor blocker telmisartan on angiotensin II-induced and estradiol-induced uterine leiomyoma cell proliferation Hum. Reprod., February 1, 2008; 23(2): 440 - 446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Baird, J. S. Kesner, and D. B. Dunson Luteinizing Hormone in Premenopausal Women May Stimulate Uterine Leiomyomata Development Reproductive Sciences, February 1, 2006; 13(2): 130 - 135. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Boynton-Jarrett, J. Rich-Edwards, S. Malspeis, S. A. Missmer, and R. Wright A Prospective Study of Hypertension and Risk of Uterine Leiomyomata Am. J. Epidemiol., April 1, 2005; 161(7): 628 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Baird Invited Commentary: Uterine Leiomyomata--We Know So Little but Could Learn So Much Am. J. Epidemiol., January 15, 2004; 159(2): 124 - 126. [Full Text] [PDF]
|
|
|
|
|
|
R. Luoto, E. Faerstein, and M. Szklo RE: "RISK FACTORS FOR UTERINE LEIOMYOMA: A PRACTICE-BASED CASE-CONTROL STUDY. II. ATHEROGENIC RISK FACTORS AND POTENTIAL SOURCES OF UTERINE IRRITATION" Am. J. Epidemiol., January 15, 2002; 155(2): 187 - 187. [Full Text] [PDF]
|
|
|
|
|
|
E. Faerstein, M. Szklo, and N. Rosenshein Risk Factors for Uterine Leiomyoma: A Practice-based Case-Control Study. I. African-American Heritage, Reproductive History, Body Size, and Smoking Am. J. Epidemiol., January 1, 2001; 153(1): 1 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Schwartz Invited Commentary: Studying the Epidemiology of Uterine Leiomyomata--Past, Present, and Future Am. J. Epidemiol., January 1, 2001; 153(1): 27 - 29. [Abstract] [Full Text] [PDF]
|
|