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American Journal of Epidemiology Vol. 108, No. 5: 350-356
Copyright © 1978 by The Johns Hopkins University School of Hygiene and Public Health

other

SINKING PRE-BETA LIPOPROTEIN AND CORONARY HEART DISEASE IN JAPANESE-AMERICAN MEN IN HAWAII

GEORGE G. RHOADS, NEWTON E. MORTON, CHRISTIAN L. GULBRANDSEN and ABRAHAM KAGAN

Honolulu Heart Study, National Heart, Lung, and Blood Institute, and the Population Genetics Laboratory and School of Public Health, University of Hawaii

Address reprint requests to: George G. Rhoads, M.D., Honolulu Heart Study, Kuakini Medical Center, 347 N. Kuakini Street, Honolulu, HI 96817.

A "sinking" pre-beta lipoprotein was sought In a probability sample of 1854, 50–72-year-old men of Japanese ancestry In Honolulu by ultracentrifugation of plasma and electrophoresis of the bottom fraction (density > 1.006) in agarose. A definite electrophoretic band was found in 5.6% of the men and a trace band was found In 4.6% of them. The frequency of such a band increased with age and decreased with adiposity. The relative risk for coronary heart disease, based on prevalence cases was found to be 1.7 in men with a definite band, and 1.4 in those with a trace band, when compared to men without. This association could not be explained by the higher low density lipoprotein levels In men with trace or definite bands. These data are consistent with previous reports suggesting that the Lp antigen (for which a sinking pre-beta lipoprotein is probably an Insensitive marker) Is associated with coronary disease.

coronary disease; Japanese; lipoproteins


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