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American Journal of Epidemiology Vol. 149, No. 1: 13-20
Copyright © 1999 by The Johns Hopkins University School of Hygiene and Public Health

other

Previous Lung Disease and Risk of Lung Cancer among Men and Women Nonsmokers

Susan T. Mayne1,, Joan Buenconsejo1 and Dwight T. Janerich2

1Department of Epidemiology and Public Health, Yale University School of Medicine New Haven, CT
2Foundation for Blood Research Portland, ME

Reprint requests to Dr. Susan T. Mayne, Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520–8034.

From 1982 to 1984, the authors conducted a population-based case-control study of lung cancer in men and women nonsmokers in New York State. In-person interviews were completed for 437 lung cancer cases (197 never smokers, 240 former smokers) and 437 matched population controls. Cases and controls were asked to report any history of physician-diagnosed nonmalignant lung disease; cases were more likely than controls to report such a history. Statistically significant associations were found for emphysema (odds ratio (OR) = 1.94, 95% confidence interval (CI) 1.10–3.43), chronic bronchitis (OR = 1.73, 95% CI 1.10–2.72), and the combined endpoint of emphysema, chronic bronchitis, or asthma (OR = 1.82, 95% CI 1.26–2.63). After adjustment for active and passive tobacco smoke exposure, emphysema, chronic bronchitis, and asthma (each condition and the combined endpoint) were significantly associated with lung cancer risk. The risk was more marked for squamous cell carcinomas and for subjects who were diagnosed at older ages, and it remained significant when surrogate interviews were excluded. These results are consistent with the hypothesis that certain prior lung conditions increase the risk of lung cancer in men and women nonsmokers. Am J Epidemiol 1999;149:13–20.

asthma; bronchitis; case-control studies; emphysema; lung diseases; lung neoplasms


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