American Journal of Epidemiology Vol. 154, No. 6 : 521-529
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Respiratory Symptoms at Age 8 Years in a Cohort of Very Low Birth Weight Children
1 Department of Preventive Medicine, University of Wisconsin Medical School, Madison, WI.
2 Department of Biostatistics and Medical Informatics, University of Wisconsin Medical School, Madison, WI.
3 Department of Statistics, College of Letters and Sciences, University of Wisconsin, Madison, WI.
4 Department of Pediatrics, University of Wisconsin Medical School, and Department of Neonatology, St. Mary's Hospital, Madison, WI.
5 Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA.
6 Department of Radiology, University of Wisconsin Medical School, Madison, WI.
The childhood respiratory consequences of very low birth weight (birth weight 
1,500 g) are incompletely understood, especially since the introduction of recent changes in neonatal care. To assess prevalence, trends, and risk factors for respiratory symptoms, the authors followed to age 8 years a cohort of 384 very low birth weight children from six regional neonatal intensive care units in Wisconsin and Iowa who were born between August 1, 1988, and June 30, 1991. A control group of 154 Wisconsin schoolchildren was also assembled. Respiratory symptoms in the past 12 months and history of asthma ("asthma ever") were reported by parents on a questionnaire used in the International Study of Asthma and Allergies in Childhood (ISAAC). Control group prevalence resembled ISAAC prevalence worldwide and in Canada, but respiratory symptoms were twice as common among very low birth weight children. With advent of the availability of pulmonary surfactants, the prevalence of wheezing at age 8 decreased from 50% to 16% (p = 0.002) among children with bronchopulmonary dysplasia, but it increased from 14% to 38% among those with milder neonatal respiratory disease. Bronchopulmonary dysplasia, family history of asthma, smoking in the household, and patent ductus arteriosus were predictive of wheezing in the previous 12 months. Antenatal steroid therapy had a borderline-significant protective association with wheezing (odds ratio = 0.56, 95% confidence interval: 0.29, 1.1). There were interaction effects between several of the predictors.
asthma; bronchopulmonary dysplasia; infant, very low birth weight; intensive care, neonatal; lung diseases, obstructive; outcome assessment (health care); pulmonary surfactants; respiratory sounds
Abbreviations: ISAAC, International Study of Asthma and Allergies in Childhood
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Baraldi and M. Filippone Chronic Lung Disease after Premature Birth N. Engl. J. Med., November 8, 2007; 357(19): 1946 - 1955. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Caudri, A. Wijga, U. Gehring, H. A. Smit, B. Brunekreef, M. Kerkhof, M. Hoekstra, J. Gerritsen, and J. C. de Jongste Respiratory Symptoms in the First 7 Years of Life and Birth Weight at Term: The PIAMA Birth Cohort Am. J. Respir. Crit. Care Med., May 15, 2007; 175(10): 1078 - 1085. [Abstract] [Full Text] [PDF]
|
|